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  • Stratification.
  • Cohort management.
  • Capping (site, country & global levels).
  • Dynamic randomization by site and/or country.
  • Unequal block sizes within the same regimen.
  • Pre-allocated ratio, block size & number of treatment arms.
 
  • Pocock & Simon minimization option.
  • Ensures balance of treatment arms.
  • Minimization of imbalance.
 
  • "Play the Winner."
  • Ability to remove inferior treatment arms mid-trial.
  • Treatment assignments depend on previous patient responses.